The antidepressants used in these studies included selective serotonin reuptake inhibitors, tricyclics, or tetracyclics. 0001 with significant heterogeneity I 2 = 76.3%). In a systematic review (26 randomized controlled trials including 1,837 patients with depression), Xiao Yao San and its modified forms combined with antidepressants were found to be superior to antidepressants alone in alleviating depression based on the Hamilton Depression Rating Scale (HAMD P <. A modified formulation with two additional herbs-Jia Wei Xiao Yao San-is also used widely to reduce anxiety and fatigue as well as to manage mood swings associated with climacteric syndrome (gradual changes of ovarian function that start before the menopause.)
Consisting of eight herbs, this formula has a long medicinal history as a remedy for relieving stress and for treating depression and anxiety. Xiao Yao San is a traditional Chinese medicine formula documented in the compendium of prescriptions written in the 11th century. 3 Although standard treatments are effective, they are associated with adverse effects such as sleep difficulties, fatigue, nausea, weight gain, anxiety, dry mouth, blurred vision, and sexual dysfunction. 1,2 Surveys also indicate that patients suffer from depressive spectrum disorders in oncologic, hematologic, and palliative settings that substantially impair quality of life. Several studies have shown higher rates of depression and anxiety in patients with cancer compared with the general population.
FREE AND EASY WANDERER FREE
Common Names: Free and Easy Wanderer, Rambling Powder, Dan Zhi Xiao Yao San, Augmented Rambling Powder, Kamishoyosan, TJ-24
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